Value of Heart Rate Variability Parameters in Prognosis of Intrauterine Infection of Infants with Cytomegalovirus

Urgency of intrauterine infection issue is conditioned not only by existing prenatal losses, but also by the fact that serious problems with state of health too frequently developed in infants with intrauterine infection managed to survive. Neonatal infectious-inflammatory process was established to take place only in 1 of 10 infants with congenital CMV infection. Still late consequences of post-natal period can be the result of subclinical variants of the process too (Noyola, Demmler, Nelsol et al., 2001; Gaytant, Rours, Steegers, Galama, and Semmekrot, 2003; Dammann, Allred, Genser et al., 2003; Schendel, 2001; Madden, Woley, Schleiss, Benton et al., 2005; Boppana, Folwer, Pass, Rivera et al., 2005; Pass, Fowler, Boppana, Britt, Stagno, 2006). Aspects of intrauterine infection effect on state of health and its prognosis in infants remain scantily explored. Study on function of autonomic nervous system (ANS) can be one of basic approaches to assessment of individual state of health in infants under risk of intrauterine infection from general adaptology point of view. Spectral analysis of heart rate variability (HRV) is an optimal approach to determination of sensitivity and specificity of executive organs to the effect of humoral, sympathetic and parasympathetic regulation (Baevskyi, 2001; Khaspekova, 2003; Kotelnikov, Nozdrachyov, Odinak et al., 2002; Kleiger, Stein, Bigger, 2005). It would be a good thing to note absence of information about stratification of CMV intrauterine infection risk in literature, HRV analysis being recently unused. The work was initiated to study spectral characteristics of HRV with its correlation regularities in infants with congenital CMV infection.